List of selected highlight publications:

Bardehle S, Kruger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M (2013) Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature Neuroscience 16: 580-586

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Arauzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR (2013) A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol 15: 295-301

Filipczyk A, Gkatzis K, Fu J, Hoppe PS, Lickert H, Anastassiadis K, Schroeder T (2013) Biallelic expression of nanog protein in mouse embryonic stem cells. Cell Stem Cell 13: 12-13

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R (2013) A localized Wnt signal orients asymmetric stem cell division in vitro. Science 339: 1445-1448

Han DW, Tapia N, Hermann A, Hemmer K, Hoing S, Arauzo-Bravo MJ, Zaehres H, Wu G, Frank S, Moritz S, Greber B, Yang JH, Lee HT, Schwamborn JC, Storch A, Schöler HR (2012) Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10: 465-472

Heinrich C, Gascon S, Masserdotti G, Lepier A, Sanchez R, Simon-Ebert T, Schroeder T, Götz M, Berninger B (2011) Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nature Protocols 6: 214-228

Marks H, Denissov S, Menafra R, Kalkan T, Jones K, Hofemeister H, Nichols J, Kranz A, Stewart AF, Smith A and Stunnenberg H. (2012) The transcriptional and epigenetic foundations of ground state pluripotency. Cell 149: 590-604

Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M (2013) The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell 13: 403-418

Ohnishi Y, Huber W, Tsumura A, Kang M, Xenopoulos P, Kurimoto K, Oles AK, Arauzo-Bravo MJ, Saitou M, Hadjantonakis AK, Hiiragi T (2014) Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nat Cell Biol 16: 27-37

Ortega F, Gascon S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Chichung Lie D, Schroeder T, Berninger B (2013) Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibitdifferential responsiveness to Wnt signalling. Nat Cell Biol 15: 602-613

Pfeiffer MJ, Esteves TC, Balbach ST, Arauzo-Bravo MJ, Stehling M, Jauch A, Houghton FD, Schwarzer C, Boiani M (2013) Reprogramming of two somatic nuclei
in the same ooplasm leads to pluripotent embryonic stem cells. Stem Cells 31: 2343-2353

Scherf N, Herberg M, Thierbach K, Zerjatke T, Kalkan T, Humphreys P, Smith A, Glauche I, Roeder I (2012) Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions. Bioinformatics 28: i556-i561

Schroeder T (2011) Long-term single-cell imaging of mammalian stem cells. Nat Methods 8: S30-35

Som A, Harder C, Greber B, Siatkowski M, Paudel Y, Warsow G, Cap C, Schöler H, Fuellen G (2010) The PluriNetWork: an electronic representation of the network underlying pluripotency in mouse, and its applications. PloS ONE 5: e15165

Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PW, Bauer C, Munzel M, Wagner M, Muller M, Khan F, Eberl HC, Mensinga A, Brinkman AB, Lephikov K, Muller U, Walter J, Boelens R, van Ingen H, Leonhardt H, Carell T, Vermeulen M (2013) Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152: 1146-1159

Tapia N, Reinhardt P, Duemmler A, Wu G, Arauzo-Bravo MJ, Esch D, Greber B, Cojocaru V, Rascon CA, Tazaki A, Kump K, Voss R, Tanaka EM, Schöler HR (2012) Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins. Nat Commun 3: 1279

Thier M, Worsdorfer P, Lakes YB, Gorris R, Herms S, Opitz T, Seiferling D, Quandel T, Hoffmann P, Nothen MM, Brustle O, Edenhofer F (2012) Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 10: 473-479

Wennekamp S, Mesecke S, Nedelec F, Hiiragi T (2013) A self-organization framework for symmetry breaking in the mammalian embryo. Nature Reviews Molecular Cell Biology 14: 452-459

Wossidlo M, Nakamura T, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Arand J, Nakano T, Reik W, Walter J (2011) 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun 2: 241

Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Schöler HR (2013) Establishment of totipotency does not depend on Oct4A. Nat Cell Biol 15: 1089-1097

Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Müller AM (2014) Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in IPS reprogramming. Stem Cells doi: 10.1002/stem.1826

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Funding Programme:

SPP 1356 Coordinator:
Prof. Dr. Albrecht Müller

Steering Committee:
Prof. Dr. Hans Robert Schöler
Prof. Dr. Jörn E. Walter
Prof. Dr. Martin Zenke